Alzheimer's disease A dementia and a tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. AD Alzheimer disease Alzheimer disease, familial Alzheimers dementia DOID:10652 EFO:0000249 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MSH:C536597 MSH:D000544 NCI:C2866 NCI:C38778 OMIM:104300 OMIM:104310 OMIM:300756 OMIM:502500 OMIM:602096 OMIM:604154 OMIM:605526 OMIM:606187 OMIM:606889 OMIM:607116 OMIM:607822 OMIM:608907 OMIM:609636 OMIM:609790 OMIM:611073 OMIM:611152 OMIM:611154 OMIM:611155 OMIM:615080 OMIM:615590 OMIM:615711 SNOMEDCT_2010_1_31:154998003 SNOMEDCT_2010_1_31:192160005 SNOMEDCT_2010_1_31:192164001 SNOMEDCT_2010_1_31:267688001 SNOMEDCT_2010_1_31:26929004 SNOMEDCT_2010_1_31:73768007 UMLS_CUI:C0002395 Xref MGI. OMIM mapping confirmed by DO. [SN]. disease_ontology dementia