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        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">bipolar disorder</rdfs:label>
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        <oboInOwl:hasExactSynonym rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mixed bipolar disorder</oboInOwl:hasExactSynonym>
        <rdfs:comment>DSM offers several different codes for bipolar, disambiguating the type of the most recent episode: 

296.8 	Bipolar Disorder NOS
296.56 	Bipolar I Disorder, Most Recent Episode Depressed, In Full Remission
296.55 	Bipolar I Disorder, Most Recent Episode Depressed, In Partial Remission
296.51 	Bipolar I Disorder, Most Recent Episode Depressed, Mild
296.52 	Bipolar I Disorder, Most Recent Episode Depressed, Moderate
296.54 	Bipolar I Disorder, Most Recent Episode Depressed, Severe With Psychotic Features
296.53 	Bipolar I Disorder, Most Recent Episode Depressed, Severe Without Psychotic Features
296.5 	Bipolar I Disorder, Most Recent Episode Depressed, Unspecified
296.4 	Bipolar I Disorder, Most Recent Episode Hypomanic
296.46 	Bipolar I Disorder, Most Recent Episode Manic, In Full Remission
296.45 	Bipolar I Disorder, Most Recent Episode Manic, In Partial Remission
296.41 	Bipolar I Disorder, Most Recent Episode Manic, Mild
296.42 	Bipolar I Disorder, Most Recent Episode Manic, Moderate
296.44 	Bipolar I Disorder, Most Recent Episode Manic, Severe With Psychotic Features
296.43 	Bipolar I Disorder, Most Recent Episode Manic, Severe Without Psychotic Features
296.4 	Bipolar I Disorder, Most Recent Episode Manic, Unspecified
296.66 	Bipolar I Disorder, Most Recent Episode Mixed, In Full Remission
296.65 	Bipolar I Disorder, Most Recent Episode Mixed, In Partial Remission
296.61 	Bipolar I Disorder, Most Recent Episode Mixed, Mild
296.62 	Bipolar I Disorder, Most Recent Episode Mixed, Moderate
296.64 	Bipolar I Disorder, Most Recent Episode Mixed, Severe With Psychotic Features
296.63 	Bipolar I Disorder, Most Recent Episode Mixed, Severe Without Psychotic Features
296.6 	Bipolar I Disorder, Most Recent Episode Mixed, Unspecified
296.7 	Bipolar I Disorder, Most Recent Episode Unspecified
296.06 	Bipolar I Disorder, Single Manic Episode, In Full Remission
296.05 	Bipolar I Disorder, Single Manic Episode, In Partial Remission
296.01 	Bipolar I Disorder, Single Manic Episode, Mild
296.02 	Bipolar I Disorder, Single Manic Episode, Moderate
296.04 	Bipolar I Disorder, Single Manic Episode, Severe With Psychotic Features
296.03 	Bipolar I Disorder, Single Manic Episode, Severe Without Psychotic Features
296 	Bipolar I Disorder, Single Manic Episode, Unspecified
296.89 	Bipolar II Disorder </rdfs:comment>
        <ns4:IAO_0000118>Bipolar affective disorder [ICD-10]</ns4:IAO_0000118>
        <rdfs:comment>Bipolar disorder or bipolar affective disorder (historically known as manic-depressive disorder) is a psychiatric diagnosis for a mood disorder in which people experience disruptive mood swings that encompass a frenzied state known as mania (or hypomania) and, usually, symptoms of depression. Bipolar disorder is defined by the presence of one or more episodes of abnormally elevated energy levels, cognition, and mood with or without one or more depressive episodes.

At the lower levels of mania, such as hypomania, individuals may appear energetic and excitable. At a higher level, individuals may behave erratically and impulsively, often making poor decisions due to unrealistic ideas about the future, and may have great difficulty with sleep. At the highest level, individuals can show psychotic behavior, including violence. Individuals who experience manic episodes also commonly experience depressive episodes, or symptoms, or a mixed state in which features of both mania and depression are present at the same time. These events are usually separated by periods of &quot;normal&quot; mood; but, in some individuals, depression and mania may rapidly alternate, which is known as rapid cycling. Severe manic episodes can sometimes lead to such psychotic symptoms as delusions and hallucinations.

The lifetime prevalence of all types of bipolar disorder is thought to be about 4% (meaning that about 4% of people experience some of the characteristic symptoms at some point in their life). Prevalence is similar in men and women and, broadly, across different cultures and ethnic groups. Genetic factors contribute substantially to the likelihood of developing bipolar disorder, and environmental factors are also implicated. Bipolar disorder is often treated with mood stabilizing medications and psychotherapy. In serious cases, in which there is a risk of harm to oneself or others, involuntary commitment may be used. These cases generally involve severe manic episodes with dangerous behavior or depressive episodes with suicidal ideation. There are widespread problems with social stigma, stereotypes, and prejudice against individuals with a diagnosis of bipolar disorder. People with bipolar disorder exhibiting psychotic symptoms can sometimes be misdiagnosed as having schizophrenia.

[Wikipedia: http://en.wikipedia.org/wiki/Bipolar_disorder]</rdfs:comment>
        <ns4:IAO_0000115>Bipolar disease is a mental disease that leads to disruptive mood swings encompassing manic and depressive moods.             </ns4:IAO_0000115>
        <ns4:IAO_0000118>bipolar disorder [DSM-IV]</ns4:IAO_0000118>
        <ns4:IAO_0000118>F31 [ICD-10 Code]</ns4:IAO_0000118>
        <priorVersion>MFOMD_0000048</priorVersion>
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