psychotic disorder schizophrenia A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. DOID:14734 DOID:5419 EFO:0000692 ICD9CM:295.8 ICD9CM:295.80 MSH:D012559 OMIM mapping confirmed by DO. [SN]. OMIM:181500 UMLS_CUI:C0029838 UMLS_CUI:C0220702 disease_ontology schizophrenia-1 295.xx - Lack of insight - Auditory hallucinations - Ideas of reference - Delusions of reference - Suspiciousness - Flatness of affect - Delusional mood - Delusions of persecution - Thought alienation - Thoughts spoken aloud ICD-10 diagnostic criteria At least one present most of the time for a month - Thought echo, insertion or withdrawal, or thought broadcast - Delusions of control referred to body parts, actions, or sensations - Delusional perception - Hallucinatory voices giving a running commentary, discussing the patient, or coming from some part of the patient’s body - Persistent bizarre or culturally inappropriate delusions Or at least two present most of the time for a month - Persistent daily hallucinations accompanied by delusions - Incoherent or irrelevant speech - Catatonic behaviour such as stupor or posturing - Negative symptoms such as marked apathy, blunted or incongruous mood F20.xx MFOMD_0000000 A long-term mental disorder of a type involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, inappropriate actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation. People with schizophrenia typically hear voices (auditory hallucinations), which often criticise or abuse them. The voices may speak directly to the patient, comment on their actions, or discuss the patients among themselves. Often this people try to make some sense of these hallucinations, and this can lead to the development of strange beliefs or delusions (mild symptoms can occur in healthy people and are not associated with illness). Schizophrenia typically presents in early adulthood or late adolescence. Men have an earlier age of onset than women, and also tend to experience a more serious form of the illness with more negative symptoms, less chance of a full recovery, and a generally worse outcome. The greatest risk factor for schizophrenia is a positive family history, although the risks in general point to an interaction between biological, psychological, and social factors that drive increasingly deviant development and finally frank psychosis. Stimulants like cocaine and amphetamines can induce a picture clinically identical to paranoid schizophrenia, and recent reports have also implicated cannabis. More than 80% of patients with their first episode of psychosis will recover, although less than 20% will never have another episode. While many patients with schizophrenia have a lifelong vulnerability to recurrent episodes of illness, a large proportion will have few relapses and make a good functional recovery. An acute onset, an obvious psychosocial precipitant, and good premorbid adjustment all can improve the prognosis. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914490/pdf/bmj-335-7610-cr-00091.pdf esquizofrenia