substance-related disorder substance dependence A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance. DOID:9973 NCI:C35458 SNOMEDCT_2010_1_31:103326000 SNOMEDCT_2010_1_31:255338002 UMLS_CUI:C0439857 disease_ontology substance addiction When an individual persists in use of alcohol or other drugs despite problems related to use of the substance, substance dependence may be diagnosed. Compulsive and repetitive use may result in tolerance to the effect of the drug and withdrawal symptoms when use is reduced or stopped. (DSM-IV, American Psychiatric Association, 2000) MFOMD_0000052 Substance dependence can be diagnosed with physiological dependence, evidence of tolerance or withdrawal, or without physiological dependence. DSM-IV substance dependencies include: 303.90 Alcohol dependence 304.00 Opioid dependence 304.10 Sedative, hypnotic, or anxiolytic dependence (including benzodiazepine dependence and barbiturate dependence) 304.20 Cocaine dependence 304.30 Cannabis dependence 304.40 Amphetamine dependence (or amphetamine-like) 304.50 Hallucinogen dependence 304.60 Inhalant dependence 304.80 Polysubstance dependence 304.90 Phencyclidine (or phencyclidine-like) dependence 304.90 Other (or unknown) substance dependence 305.10 Nicotine dependence [Wikipedia:http://en.wikipedia.org/wiki/Addiction] ICD-10 codes F10-F19 [WHO ICD:http://apps.who.int/classifications/icd10/browse/2010/en#/F10-F19] addiction disorder