synthetic genetic interaction aphenotypic diverging genetic interaction An effect in which two genetic perturbations, when combined, result in a mutant phenotype that is not observed (or minimally observed) as a result of any of the individual perturbations. wt = a = b = E (not=) ab synthetic genetic interaction (sensu inequality) synthetic genetic interaction defined by inequality PSI-MI MI:0794 diverging genetic interaction aphenotypic phenotype result