interaction attribute name pre-assembly response altered physicochemical compatibility PSI-MI MI:1172 2012-06-07T01:26:56Z orchard The addition of a PTM to an interaction interface affects the physicochemical compatibility of the binding site with its binding partner. This can either induce or enhance an interaction, or result in inhibition or even abrogation of an interaction. Multisite modification can mediate rheostatic regulation of the interaction.