thiazide sulfonamide antibiotic trichlormethiazide 378.902 380.658 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O C8H8Cl3N3O4S2 CAS:133-67-5 CHEBI:9683 DrugBank:DB01021 Drug_Central:2733 InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16) KEGG:C07767 KEGG:D00658 LINCS:LSM-4383 LMJSLTNSBFUCMU-UHFFFAOYSA-N PMID:21605415 PMID:24678944 PMID:25692026 PMID:25938807 PMID:28089902 PMID:28166217 Wikipedia:Trichlormethiazide chebi_ontology hydrotrichlorothiazide trichlormethiazide trichlormethiazidum triclormetiazida