antifungal allylamines Sydney Cohen Allylamines are a group of antifungals that inhibit ergosterol synthesis at the level of squalene epoxidase. Their mechanism is competitive inhibition of squalene epoxidase, blocking conversion of squalene to lanosterol, leading to squaline accumulation and ergosterol depletion in the cell membrane. https://www.merckvetmanual.com/pharmacology/antifungal-agents/allylamines-for-use-in-animals https://doi.org/10.1016/0190-9622(90)70288-s These agents are highly selective for the fungal enzyme and have a minimal effect on mammalian cholesterol synthesis.