patch clamp technique whole-cell patch clamp technique 2012-08-09T01:19:30Z A patch clamp technique which uses an electrode inserted into an intact cell in such a way that a high resistance seal is maintained between the electrode and the plasma membrane, allowing measurement of currents through multiple ion channels across the entire cell membrane. JSmith MMO:0000293 measurement_method_ontology whole cell patch clamp recording whole-cell patch-clamp technique