L-2-aminoadipic acid (2S)-2-aminohexanedioic acid 14.96327972412109375 14.970000267028808594 143.0582427978515625 143.1399993896484375 2-amino-1,4-butanedicarboxylic acid A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid. C 0 H -3 N -1 O 2 C 6 H 9 N 1 O 3 From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG] K L-2-aminoadipic acid L-alpha-aminoadipic acid Lys->AminoadipicAcid Lysoic MOD:00131 Oxidation of lysine (to aminoadipic acid) PSI-MOD Unimod:381 alpha-amino adipic acid natural modified L-lysine residue