modified L-tyrosine residue iTRAQ8plex-119 reporter+balance reagent acylated residue iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5 (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3 (4-methylpiperazin-1-yl)acetyl 304.19903564453125 304.20001220703125 467.260009765625 467.262359619140625 A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group. Accurate mass for 115, 118, 119 & 121 Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry MOD:01573 PSI-MOD The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification. Unimod:731 Y artifact iTRAQ8plex:13C(6)15N(2) iTRAQ8plex reporter+balance reagent O-acylated residue