disease disrupts disease causes disruption of cortisol biosynthetic process adrenocortical insufficiency https://www.malacards.org/card/adrenal_cortical_hypofunction MEDGEN:589758 UMLS:C0405580 adrenocortical insufficiency hypoadrenalism NCIT:C26691 adrenal gland insufficiency EFO:0009491 MONDO:0000004 MESH:D000309 DOID:10493 hypocortisolemia adrenal insufficiency SCTID:386584007 hypocortisolism ICD9:255.41 adrenal cortical hypofunction ICD9:255.4 adrenal cortical insufficiency An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency). icd11.foundation:733056203 adrenal cortex disorder