disease has feature Irritability Lethargy parenchymatous neurosyphilis https://www.malacards.org/card/parenchymatous_neurosyphilis MONDO:0000335 A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has symptom irritability, has symptom difficulty concentrating, has symptom deterioration of memory, has symptom defective judgment, has symptom headaches, has symptom insomnia, has symptom fatigue, and has symptom lethargy. DOID:0050490 GARD:0022749 neurosyphilis insomnia