selective IgA deficiency disease https://github.com/monarch-initiative/mondo/issues/9285 https://www.malacards.org/card/immunoglobulin_a_deficiency_1 https://www.malacards.org/card/immunoglobulin_alpha_deficiency DOID:11701 EFO:1001929 Orphanet:69127 MONDO:0001341 NCIT:C26964 NANDO:1200347 DOID:0060025 deficiency, IgA immunoglobulin A deficiency UMLS:C4049006 deficiencies, IgA NANDO:2200720 IgA deficiencies selective IgA immunodeficiency MESH:D017098 SIgAD A dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class A (IgA). It is the most common primary antibody deficiency. It may be inherited or the reversible sequela of infection or certain drugs. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Though affected persons may be asymptomatic, low levels of IgA will reduce the immune system's ability to combat infection where IgA is normally secreted, at mucosal surfaces. Selective IgA deficiency is seen in greater proportion among patients with autoimmune disorders. GARD:0027574 SCTID:29260007 MEDGEN:883982 dysgammaglobulinemia