hepatic encephalopathy https://rarediseases.info.nih.gov/diseases/10452/hepatic-encephalopathy https://www.malacards.org/card/hepatic_encephalopathy MESH:D006501 MONDO:0001711 UMLS:C0019151 portal-systemic encephalopathy GARD:0027587 Hepatoencephalopathy DOID:13413 MEDGEN:5513 SCTID:13920009 Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.Signs and symptomsmay be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may includepersonality or moodchanges, intellectual impairment, abnormal movements,a depressed level of consciousness, and other symptoms.There are several theories regarding the exact cause, butdevelopment of the condition isprobablyat least partiallydue to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis. icd11.foundation:1769383160 NCIT:C79596 ICD9:572.2 encephalopathy, hepatic toxic encephalopathy brain disorder