disease has basis in disruption of disease caused by disruption of erythrocyte homeostasis anemia A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. anaemia (disease) SCTID:271737000 MEDGEN:1526 anemia (disease) MESH:D000740 HP:0001903 ICD9:285.9 ICD9:285.8 anemia (disease) UMLS:C0002871 DOID:2355 MONDO:0002280 anemia NCIT:C2869 hematologic disorder