disease disrupts disease causes disruption of negative regulation of blood coagulation protein S deficiency https://rarediseases.info.nih.gov/diseases/4524/protein-s-deficiency https://www.malacards.org/card/protein_s_deficiency NANDO:2100198 MONDO:0002304 MESH:D018455 NCIT:C99026 HGNC:9456 UMLS:C0242666 DOID:2451 ICD9:289.81 Editor note: TODO axiomatize Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding. Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulatednormally and affected individuals have an increased risk of forming a blood clot called a thrombosis. People at risk to haveprotein S deficiency are those with an individual or family history of multiple blood clots in the veins. Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot. NANDO:1201081 SCTID:1563006 Protein S deficiency disease Protein S deficiency NANDO:2200690 MEDGEN:69229 thrombophilia