disease has location hepatic porphyria https://www.malacards.org/card/acute_porphyria MONDO:0002520 ALAD deficiency GTR:AN0932921 porphyria, hepatic MESH:D017094 GARD:0019255 acute hepatic porphyria acute porphyria hepatic Porphyrias liver porphyria UMLS:C0162533 Orphanet:659694 DOID:3133 hepatic porphyria porphyria of liver SCTID:55056006 porphobilinogen synthase deficiency A group of metabolic diseases due to deficiency of one of a number of liver enzymes in the biosynthetic pathway of heme. They are characterized by the accumulation and increased excretion of porphyrins or its precursors. Clinical features include neurological symptoms (porphyria, acute intermittent), cutaneous lesions due to photosensitivity (porphyria cutanea tarda), or both (hereditary coproporphyria). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues. MEDGEN:58119 Delta-aminolevulinate dehydratase deficiency liver disorder obsolete rare hereditary metabolic disease with peripheral neuropathy inherited porphyria obsolete genetic skin disease porphyria liver