disease arises from structure disease arises from alteration in structure disease shares features of keratoacanthoma https://www.malacards.org/card/keratoacanthoma MESH:D007636 ICDO:8071/1 A dome-shaped, rapidly growing skin lesion composed of well differentiated squamous cells. It represents a proliferation of the infundibular epithelium of the hair follicle and its morphologic distinction from a well differentiated carcinoma may be difficult or impossible. Keratoacanthomas affect males more frequently than females and the majority tend to regress spontaneously. It has been suggested that keratoacanthoma represents a distinct subtype of squamous cell carcinoma of the skin. UMLS:C0022572 icd11.foundation:516478127 NCIT:C3146 MEDGEN:5954 Clinically and histologically, it may be confused with a de novo highly malignant squamous cell carcinoma (SCC). However, KA may be viewed as an abortive cancer that only rarely progresses into an aggressive SCC - PMID:8277007. SCTID:254662007 DOID:3149 MONDO:0002527 skin squamous cell carcinoma squamous cell carcinoma epithelial skin neoplasm hair follicle