disease arises from structure disease arises from alteration in structure bone osteosarcoma conventional osteosarcoma https://www.malacards.org/card/conventional_osteosarcoma medullary osteosarcoma DOID:7602 MONDO:0002631 UMLS:C5848244 NCIT:C35870 conventional central osteosarcoma intracortical osteogenic sarcoma ICDO:9195/3 intracortical osteosarcoma MEDGEN:1843980 DOID:3378 GARD:0023198 central osteosarcoma intracortical osteosarcoma (morphologic abnormality) ICDO:9186/3 A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. The tumor arises from the medullary portion of the bone. It affects the long bones and most commonly, the distal femur, proximal tibia, and proximal humerus. Pain with or without a palpable mass is the most common clinical presentation. It usually has an aggressive growth and may metastasize through the hematogenous route. The lung is the most frequent site of metastasis. conventional osteosarcoma stroma of bone marrow