disease has location syndromic disease superior mesenteric artery syndrome https://rarediseases.info.nih.gov/diseases/7712/superior-mesenteric-artery-syndrome https://www.malacards.org/card/superior_mesenteric_artery_syndrome NORD:1955 syndromic disease of superior mesenteric artery MEDGEN:21404 NCIT:C85175 MONDO:0002687 superior mesenteric artery syndrome Cast syndrome Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due toloss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment. Orphanet:622099 UMLS:C0038828 superior mesenteric artery syndromic disease MESH:D013478 Arteriomesenteric duodenal compression syndrome DOID:3557 SCTID:197006009 vascular compression of the duodenum Wilkie syndrome GARD:0007712 duodenal obstruction aortic disorder superior mesenteric artery