acute necrotizing encephalitis https://www.malacards.org/card/acute_necrotizing_encephalitis MONDO:0003336 ANE acute necrotizing encephalopathy DOID:5222 acute necrotizing encephalitis UMLS:C0338418 SCTID:111897007 GARD:0013233 A fulminant and often fatal demyelinating disease of the brain which primarily affects young adults and children. Clinical features include the rapid onset of weakness, seizures, and coma. It may follow a viral illness or mycoplasma pneumoniae infections but in most instances there is no precipitating event. Pathologic examination reveals marked perivascular demyelination and necrosis of white matter with microhemorrhages. (Adams et al., Principles of Neurology, 6th ed, pp924-5) MEDGEN:83264 NCIT:C35383 ICD9:049.8 viral encephalitis