skin pilomatrix carcinoma https://www.malacards.org/card/pilomatrix_carcinoma https://www.malacards.org/card/skin_pilomatrix_carcinoma pilomatrix carcinoma of the skin GARD:0022042 calcifying epitheliocarcinoma pilomatrix carcinoma of skin Orphanet:499182 MEDGEN:108439 pilomatrix carcinoma DOID:5376 pilomatrix skin carcinoma SCTID:307610008 malignant pilomatricoma calcified epithelial carcinoma of Malherbe matrical carcinoma NCIT:C4114 Pilomatrical carcinoma Trichomatrical carcinoma invasive pilomatrixoma ICDO:8110/3 A very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites. MONDO:0003414 UMLS:C0585475 skin appendage carcinoma obsolete rare skin tumor or hamartoma