disease arises from structure disease arises from alteration in structure naive B cell chronic lymphocytic leukemia/small lymphocytic lymphoma pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma https://www.malacards.org/card/pregerminal_center_chronic_lymphocytic_leukemia_small_lymphocytic_lymphoma NCIT:C37204 MEDGEN:234146 A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years. pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma UMLS:C1333038 CLL/SLL with unmutated IGVH chronic lymphocytic leukemia/small lymphocytic lymphoma with unmutated Immunoglobulin heavy chain variable-region Gene MONDO:0004478 DOID:8144 GARD:0024026