substance-related disorder substance dependence https://www.malacards.org/card/substance_dependence UMLS:C0038580 SCTID:2403008 MONDO:0004938 dependence NCIT:C35458 MEDGEN:20989 The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence. ICD9:304.60 DOID:9973