eosinophilia-myalgia syndrome https://rarediseases.info.nih.gov/diseases/6345/eosinophilia-myalgia-syndrome https://www.malacards.org/card/eosinophilia_myalgia_syndrome severe muscle pain and abnormally high eosinophils EFO:1001316 SCTID:95416007 GARD:0006345 eosinophilia myalgia syndrome syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart EMS DOID:998 UMLS:C0085179 NORD:1094 MEDGEN:38987 L-tryptophan induced EMS ICD9:710.5 MESH:D016603 icd11.foundation:1361333197 MONDO:0004941 A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include eosinophilia, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn wd, Semin Arthritis Rheum 1997 Jun;26(6):788-93) hypereosinophilic syndrome