disease arises from structure disease arises from alteration in structure mature B cell B-cell neoplasm neoplasm of mature B-cells https://www.malacards.org/card/mature_b_cell_neoplasm A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001). NCIT:C27910 mature B-cell lymphocytic neoplasm mature B-cell neoplasms SCTID:269476000 EFO:0000096 UMLS:C1334633 mature B-cell neoplasm ONCOTREE:MBN GARD:0024136 Editor note: is a non-hodgkin in ONCOTREE MEDGEN:235305 MONDO:0004949 DOID:706 ICD9:202.0 neoplasm