neuroendocrine carcinoma large cell neuroendocrine carcinoma https://www.malacards.org/card/large_cell_neuroendocrine_carcinoma icd11.foundation:1278312485 MONDO:0005057 UMLS:C1265996 large-cell neuroendocrine carcinoma LCNEC NCIT:C6875 A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas. ICDO:8013/3 GARD:0024145 ONCOTREE:LUNE large cell neuroendocrine carcinoma MEDGEN:220402 EFO:0000563 large cell NEC DOID:0050872 large cell carcinoma