disease arises from structure disease arises from alteration in structure neuroblast (sensu Vertebrata) autonomic nervous system neoplasm neuroblastoma https://rarediseases.info.nih.gov/diseases/7185/neuroblastoma https://www.malacards.org/card/neuroblastoma MESH:D009447 neuroblastoma NB is a disease of the sympaticoadrenal lineage of the neural crest, with tumors forming anywhere in the sympathetic nervous system. The tumors most commonly arise in the abdomen (65%), however, they also occur in the neck, chest, and pelvis. Approximately 50% of patients present with evidence of metastasis. Frequent metastasis sites include cortical bone, bone marrow, liver, and lymph nodes. The most common genetic change is MYCN amplification, which occurs in approximately 20% of patients, and is strongly correlated with advanced stage NB. Additionally, deletions of the short arm of chromosome 1 (1p) are found in 25–35% of patients and can be correlated with MYCN amplification. Outside of MYC linked changes, allelic loss of 11q is present in 35–45% of patients and is also associated with high-risk disease features. neural Crest tumor, malignant ICDO:9500/3 MEDGEN:18012 neuroblastoma (Schwannian Stroma-poor) Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system. UMLS:C0027819 EFO:0000621 NANDO:2200040 SCTID:432328008 NCIT:C3270 DOID:769 neuroblastoma, malignant Orphanet:635 birnlex:12631 ONCOTREE:NBL MONDO:0005072 NB MedDRA:10029260 GARD:0007185 neuroblastic tumor central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor neurocristopathy