autoimmune disorder of gastrointestinal tract hereditary disease celiac disease https://www.malacards.org/card/celiac_disease MESH:D002446 gluten intolerance DOID:10608 gluten-induced enteropathy NCIT:C26714 coeliac sprue non tropical sprue UMLS:C0007570 OMIMPS:212750 icd11.foundation:2005943638 An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet. celiac sprue EFO:0001060 ICD10CM:K90.0 Orphanet:555 celiac disease MEDGEN:3291 ICD9:579.0 MONDO:0005130 SCTID:396331005 malabsorption syndrome small intestine disorder