experimental autoimmune encephalomyelitis An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenized brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis. https://github.com/monarch-initiative/mondo/issues/7325 MONDO:0005134 MESH:D004681 EFO:0001066 encephalomyelitis CNS demyelinating autoimmune disease nervous system disorder, non-human animal