congenital nervous system disorder ophthalmoplegia progressive external ophthalmoplegia https://www.malacards.org/card/chronic_progressive_external_ophthalmoplegia chronic progressive external ophthalmoplegia [ambiguous] MONDO:0005181 HP:0000590 icd11.foundation:1698427219 UMLS:C0162674 SCTID:46252003 EFO:0002509 GARD:0004503 NANDO:1200174 ICD9:378.72 Orphanet:520820 A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422) MESH:D017246 ICD10CM:H49.4 MEDGEN:102439 DOID:12558 progressive external ophthalmoplegia inborn mitochondrial myopathy hereditary neurological disease