cardiovascular disorder ischemia reperfusion injury Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury. PMID:10685060 EFO:0002687 MESH:D015427 MONDO:0005203 injury