realized in response to realized in response to exposure to drug substance dependence mental disorder drug dependence https://www.malacards.org/card/drug_dependence chemical dependence ICD9:304.6 UMLS:C1510472 ICD9:304.90 Drug dependence - replaced the term "drug addiction" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug. EFO:0003890 NCIT:C3894 MONDO:0005303 DOID:9974 ICD9:304 ICD9:304.60 MEDGEN:307144 SCTID:191816009