Creutzfeldt Jacob disease https://www.malacards.org/card/creutzfeldt_jakob_disease NORD:1014 GARD:0024173 Creutzfeldt Jakob Disease Creutzfeldt-Jacob disease CJD (Creutzfeldt Jakob disease) NCIT:C26802 MONDO:0005357 MEDGEN:7179 DOID:11949 MESH:D007562 Jakob-Creutzfeldt disease EFO:0004226 ICD9:046.19 ICD9:046.1 classic Creutzfeldt-Jakob disease UMLS:C0022336 CJD SCTID:792004 A rare transmittable degenerative disorder of the brain caused by prions. Morphologically it is characterized by spongiform degeneration of the cerebral and cerebellar cortex. Signs and symptoms include sleep disturbances, personality changes, aphasia, ataxia, muscle atrophy and weakness, visual loss, and myoclonus. It usually leads to death within a year from the onset of the disease. prion disease