realized in realized in realized in response to stimulus PRNP disease prion disease https://www.malacards.org/card/prion_disease MONDO:0005429 A transmissible disease that is caused by a protein that is able to induce abnormal folding of normal cellular proteins, leading to characteristic spongiform brain changes, which are associated with neuronal loss without an inflammatory response. Such disorders have typically long incubation periods, but are then generally rapidly progressive and are uniformly fatal. DOID:649 MESH:D017096 NCIT:C128346 GARD:0024183 NANDO:1200186 spongiform encephalopathy ICD9:046.19 UMLS:C0162534 Editor note: check relationship to spongiform encephalopathy NCIT:C27585 SCTID:230284004 MEDGEN:56445 EFO:0004720 brain disorder central nervous system infectious disorder Disease Transmission