disease has feature Decreased circulating vitamin D concentration bone remodeling disease rickets https://www.malacards.org/card/rickets active rickets MONDO:0005520 GARD:0005700 vitamin D hydroxylation-deficient rickets nutritional rickets ICD9:268.0 Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities. rickets (disease) hypovitaminosis D HP:0002748 UMLS:C0035579 MESH:D012279 MEDGEN:48470 rickets (disease) rickets NCIT:C26878 DOID:10609 vitamin D deficiency disease rachitis SCTID:41345002 EFO:0005583 vitamin-D deficiency rickets