disease has feature Neurofibrillary tangles neurodegenerative disease tauopathy https://www.malacards.org/card/tauopathy UMLS:C0949664 MONDO:0005574 EFO:0005815 MEDGEN:181880 Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (tau proteins) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with alzheimer disease; dementia; parkinsonian disorders; progressive supranuclear palsy (supranuclear palsy, progressive); and corticobasal degeneration. DOID:680 MESH:D024801 disease by molecular mechanism