type IV hypersensitivity disease cryoglobulinemia https://rarediseases.info.nih.gov/diseases/6217/cryoglobulinemia https://www.malacards.org/card/cryoglobulinemia ICD10CM:D89.1 MESH:D003449 NCIT:C26736 UMLS:C0010403 DOID:2917 ICD9:273.2 MONDO:0005576 MEDGEN:3673 SCTID:30911005 cryoglobulinemia Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. EFO:0005846 autoimmune disease