disease has feature Decreased total lymphocyte count T-cell immunodeficiency lymphopenia idiopathic CD4-positive T-lymphocytopenia https://www.malacards.org/card/idiopathic_cd4_positive_t_lymphocytopenia GARD:0024233 UMLS:C0206744 DOID:3109 MESH:D018344 MEDGEN:64647 MONDO:0005807 NCIT:C84780 A rare immunodeficiency syndrome characterized by the decrease of the CD4-positive lymphocytes below 300 per cubic millimeter in the absence of identifiable immunodeficiency causes. Patients with this syndrome are at an increased risk of opportunistic infections. idiopathic disease