skeletal system disorder rheumatic disorder mixed connective tissue disease https://rarediseases.info.nih.gov/diseases/7051/mixed-connective-tissue-disease https://www.malacards.org/card/mixed_connective_tissue_disease MedDRA:10027754 NCIT:C84892 NANDO:2200430 sharp syndrome MESH:D008947 NORD:1451 Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms. MONDO:0005854 EFO:0007374 MCTD MEDGEN:10069 GARD:0007051 UMLS:C0026272 SCTID:398049005 Orphanet:809 NANDO:1200278 DOID:3492 icd11.foundation:891652224 overlapping connective tissue disease obsolete secondary glomerular disease