disease has location disease arises from structure disease arises from alteration in structure digestive system cancer adenoma digestive system adenoma https://www.malacards.org/card/gastrointestinal_adenoma MEDGEN:184920 digestive system adenoma MONDO:0006180 EFO:1000217 UMLS:C0948101 gastrointestinal adenoma DOID:4147 NCIT:C36207 digestive tract adenoma A sporadic or less frequently familial neoplasm, arising from the glandular epithelium of the stomach, small intestine, biliary tract, colon, and rectum. It is a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger adenomas with severe dysplastic changes (sometimes called carcinoma in situ) carry a higher risk of progressing to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. Familial adenomas tend to be multifocal and carry a higher risk of malignant transformation. digestive system neoplasm digestive tract glandular epithelium