aortic valve disorder aortic valve prolapse https://www.malacards.org/card/aortic_valve_prolapse MedDRA:10057454 MEDGEN:1619 The downward displacement of the cuspal or pointed end of the trileaflet aortic valve causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ascending aorta back into the left ventricle, leading to aortic regurgitation. DOID:5232 MONDO:0006655 UMLS:C0003505 MESH:D001023