brain disorder brain edema https://www.malacards.org/card/brain_edema UMLS:C0006114 MedDRA:10006121 DOID:4724 EFO:1000845 ICD9:348.5 MEDGEN:2337 MESH:D001929 MONDO:0006684 SCTID:2032001 Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see hypoxia, brain). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of csf flow (e.g., obstructive hydrocephalus). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)