syndromic disease pituitary gland disorder empty sella syndrome https://rarediseases.info.nih.gov/diseases/6331/empty-sella-syndrome https://www.malacards.org/card/empty_sella_syndrome empty sella syndrome Empty sella syndrome (ESS) is a condition that involves the sella turcica, a bony structure at the base of the brain that protects the pituitary gland. There is a primary and secondary form of the condition. The primary form occurs when a structural defect above the pituitary gland increases pressure in the sella turcica and causes the gland to flatten. The secondary form occurs when the pituitary gland is damaged due to injury, a tumor, surgery or radiation therapy. Some people with ESS have no symptoms. People with secondary ESS may have symptoms of decreased pituitary function such as absence of menstruation, infertility, fatigue, and intolerance to stress and infection. In children, ESS may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction. Treatment focuses on the symptoms present in each person. DOID:3642 NCIT:C84686 ICD9:253.8 icd11.foundation:49112094 empty sella turcica GARD:0027764 MESH:D004652 EFO:1000914 UMLS:C0014008 MEDGEN:41766 SCTID:237722004 MedDRA:10014567 empty sella MONDO:0006740