has material basis in germline mutation in ATP2A2 keratosis acrokeratosis verruciformis https://www.malacards.org/card/acrokeratosis_verruciformis MEDGEN:75589 acrokeratosis verruciformis of Hopf EFO:1000666 SCTID:400085009 MedDRA:10069445 DOID:0050606 acrokeratosis verruciformis OMIM:101900 Orphanet:79151 ICD9:757.39 GARD:0016707 UMLS:C0265971 MONDO:0007048 AKV of Hopf Hopf disease AKV NCIT:C27519 A rare genetic skin keratinization disorder with an autosomal dominant mode of inheritance. It is characterized by numerous flesh-colored warty papules on the back of the hands, medial aspect of the feet, knees, and elbows. hereditary skin disorder