syndromic intellectual disability integumentary system disorder syndromic disease hereditary disease alopecia-epilepsy-pyorrhea-intellectual disability syndrome https://github.com/monarch-initiative/mondo/issues/5588 https://github.com/monarch-initiative/mondo/issues/6749 https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/alopecia_psychomotor_epilepsy_pyorrhea_and_mental_subnormality MESH:C537057 congenital universal alopecia, epilepsy, mental subnormality and pyorrhea Alopecia-epilepsy-pyorrhea-intellectual disability syndrome is characterized by congenital permanent alopecia universalis, intellectual disability, psychomotor epilepsy and periodontitis (pyorrhea). Total permanent alopecia and pyorrhea are invariably concomitant while intellectual disability and psychomotor epilepsy are observed in most patients. No other abnormality of nails or skin (apart from absence of hair) has been reported. Transmission is autosomal dominant. MONDO:0007085 MEDGEN:350833 Shokeir syndrome GARD:0000607 OMIM:104130 SCTID:720980004 Orphanet:1008 UMLS:C1863090 alopecia, epilepsy, pyorrhea, mental subnormality