has material basis in germline mutation in disease has feature COL1A1 Irritability hyperostosis bone inflammation disease Caffey disease https://github.com/monarch-initiative/mondo/issues/4948 https://www.malacards.org/card/caffey_disease UMLS:C0020497 MEDGEN:43781 Orphanet:1310 Caffey disease SCTID:24752008 Caffey disease is an osteosclerotic dysplasia characterized by acute inflammation with massive subperiosteal new bone formation usually involving the diaphyses of the long bones, as well as the ribs, mandible, scapulae, and clavicles. The disease is associated with fever, irritability pain and soft tissue swelling, with onset around the age of 2 months and resolving spontaneously by the age of 2 years. However, prenatal disease onset has also been described. NCIT:C118423 infantile cortical hyperostosis ICD9:756.59 OMIM:114000 MESH:D006958 DOID:4257 GARD:0001051 MONDO:0007244 neonatal osteosclerotic dysplasia