has material basis in germline mutation in PIEZO2 Gordon syndrome https://rarediseases.info.nih.gov/diseases/2553/gordon-syndrome https://www.malacards.org/card/arthrogryposis_distal_type_3 An extremely rare multiple congenital malformation syndrome characterized by congenital contractures of hand and feet with variable degrees of severity of camptodactyly, clubfoot and, less frequently, cleft palate. Intelligence is normal but in some cases, additional abnormalities, such as short stature, kyphoscoliosis, ptosis, micrognathia, and cryptorchidism may also be present. Gordon syndrome, Marden-Walker syndrome and arthrogryposis with oculomotor limitation and electroretinal anomalies clinically and genetically overlap, and could represent variable expressions of the same condition. MEDGEN:66314 Orphanet:376 NORD:1199 MONDO:0007252 OMIM:114300 DOID:0111607 camptodactyly-cleft palate-clubfoot syndrome distal arthrogryposis type 3 MESH:C537288 DA3 UMLS:C0220666 Gordon syndrome distal arthrogryposis type IIA arthrogryposis, distal, type 3 GARD:0002553 SCTID:237850008 ICD9:579.8 arthrogryposis distal type 3 multiple congenital anomalies/dysmorphic syndrome without intellectual disability distal arthrogryposis