has characteristic has characteristic has material basis in germline mutation in MSH2 Autosomal dominant inheritance Lynch syndrome Lynch syndrome 1 https://github.com/monarch-initiative/mondo/issues/9178 https://www.malacards.org/card/lynch_syndrome_1 An autosomal dominant hereditary neoplastic syndrome caused by pathogenic variants in the MSH2 mismatch repair gene. It is characterized by an increased risk of colorectal cancer in the absense of extensive polyposis, endometrial, ovarian, gastric, small intestinal, and urinary tract cancers, often occuring at younger ages. OMIM:120435 Lynch syndrome type 1 MEDGEN:423615 Lynch 1 syndrome MONDO:0007356 MESH:C537261 Lynch syndrome 1 GARD:0015052 familial non-polyposis colon cancer type 1 UMLS:C2936783 DOID:0070271 COCA1 Hereditary non-polyposis colon cancer type 1 NCIT:C6725 hereditary nonpolyposis colorectal cancer type 1 MSH2-related Lynch syndrome HNPCC1 hereditary nonpolyposis colon cancer